I am still quite new to linux myself and I am trying several distros to find the one which suits me best. Today I tried Pop!OS 21.04 and at the beginning I had your same issue, but I managed to solve it quite easily.
First I installed the latest development release of Wine. Then Lutris. In lutris, I installed Zbrush with the default settings, choosing Wine as the runner.
During the installation, I accepted all the additional installations required.
I started Zbrush and I saw I had your issue. I closed it, I choose “configure” from the Lutris menu, and installed the lutris runner. I closed and restarted lutris, I again clicked “configure” for Zbrush, then changed the runner from Wine to Lutris. Started Zbrush and the issue was solved, but my stylus was acting weird. So I closed Zbrush, reverted back the runner and finally everything works correctly.