For the purposes of texturing, normal map creation and standard displacement map creation you can only have one UV region/tile (0,0 to 1,1). All other UV regions are overlaid the first UV region. It is natural that a UV check will show many areas with red.
With the Zplugin > Multi Displacement plugin you can utilise the extra UV regions to create multiple displacement maps. So in other words, ZBrush does register the multiple UV regions but can not currently (ZBbrush 2) utilise them for anything but assigning Polygroups and creating multiple displacement maps .
Of course when you press Tool > Polygroups > UV Groups you can quickly select which part of the geometry, and hence, which UV region you want to work on. So you can work with multiple textures that way, but you will not be able to view them all at once.
I am guessing a future version of ZBrush might use UV regions as a means to paint on multiple textures?