Your reference model could be slightly asymmetrical or off center. Sometimes, you just miss a connection target somewhere along the line, and it messes up work you do subsequently. And I’ve noticed that ZB does much better when there is a clear centerline down the middle.
In either event, dont worry overmuch about it. Once you complete the mesh and generate the skin, its a simple matter to resymmetrize it with Smart Resym, or the new Mirror Weld function.
In the meantime, In the topology palette, set Max Strip length to 4. This will let you see explicitly any missed targets or Ngons, as it wont “connect the dots” unless your polys are exactly quads or tris, and you’ll see a hole there. If set higher, Zbrush will attempt to fill in those gaps during the preview, and you might not detect problems until much later.