Hi I was having a lot of trouble with zbrush, it would frequently crash on the startup screen and often throw me out at random times during modeling. After some emailing to zbrush tech support they suggested the following -
"Could you check if you have Data Execution Prevention turned on for applications? If you do, could you turn it off and try ZBrush3 again?
To do this, you go to Start/My Computer and right click and select Properties. You go to the Advanced tab, choose the Performance section Settings button and then the Data Execution Prevention tab. Make sure “( )Turn on DEP for all programs and services except those I select” is off."
Followed their advice and now the program is running very well. Starts up every time.
Hope this is useful if anyone else if having similar issues with their zbrush on an athlon 64 machine.
Cheers (and thanks again to zbrush support - excellent job guys)