Probably answered my own question 
. What is the best method to use? Sculpt then pose or pose then sculpt. I ask because the model I’m working on I posed first and am now running into to problem mainly with symmetry/pose able symmetry.
depends on your skill level and comfort I suppose.
symmetry is a life saver in regards to speed, but hinders your ability to sculpt because you’re always only sculpting one side at a time (something that you can’t do in real life).
Anyway, if you want basic ideas and things that don’t really change then you can sculpt with sym to start, break that sym for posing, and then change the sculpture to fit the change in balance and form that the new pose brings.
I do a T-pose first, sculpting it symmetrical. Then I add asymmetric details, before I pose and make the final adjustments. Posing will always change how a muscle etc. looks.
I do believe there is a feature within zbrush that allows you to sculpt symmetrical on a posed mesh too.
Oh thx for the help! I enjoy this.
If i want do add clothes. Is it better to extrude them from the posed mesh? I think clothes are the real problem in that case.
To my skill level. i am skilled at cinema 4d, used it for many years. there are functions like cloth that allows realistic falling clothes, wind etc.
but if i am making a skirt, so its not close to body. better to do that outside of zbrush?
do you guys know any workflow dvd where this topic is solved?
but i guessed t-pose would be best for beginning, yea. But as zbrush beginner i ask my self… sculpting moods, like a smile and so on, how to do that best.
and my biggest worry… are the UVs… If I sculpt my clothes and try to apply structure, seamless bump, so that they look realistic. How to do this? does the zbrush uv plugin handle such problems good? on clothes with detail?
this is sth i must know. it would actually help me a lot! The technical thing is what i dont understand, not so much the artistic, this part is no problem.
It always scares me to transpose a model after I sculpt it. you mask off the area, bend it and when you done the connecting mesh area around the mask edge stretch all wonky. :o
Granted I’m a rookie with Zbrush.
I know I will get better at it over time… just makes my heart jump when I transpose. I know this is how the pros do it. I Keep being told to start off with a “T” pose or a “Da Vinci” pose.
It’s definitely not a good idea to model in t-pose and then pose the finished multimillion mesh. Muscles, clothes etc. change shape so drastically that it’s practically impossible to pose a finished model properly. I guess the best way is to pose before reaching too high subd levels.
My problem is that pose able symmetry seems to be busted on the current model I’m working on. I do not mind having no symmetry as I’m a traditional sculptor, but it would have been nice to have sculpted my very first symmetrical piece 
.