Here are my ten reasons why Zbrush is better than Mudbox for Video Game Artists.
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The ability to transpose your model in order to create multiple versions of your sculpt to achieve different appearances of clothing folds. This is very useful for normal map blending in your game shader.
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Dropping to 2.5D mode in order to create tiling sculpts that can either be used as Normal Maps or Stencils inside of Zbrush. Very handy for environment artists.
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ZApplink
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Start with ZSpheres to quickly mock-in designs for quick iterations on sculpts rather than having to work in a 3D App first to import a base mesh
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Retoplogy Tools for quickly constructing a new game mesh based on the sculpt.
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Quick renders and turntables for sign-off purposes with Art Director.
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The ability to record tutorials within ZBrush to help train other artists. No need to use a program like Camtasia.
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More brush options for sculpting.
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Polygroups and SubTools to help keep sculpt organized.
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Great community support (ZBrush Central)